Global Competition

This week, the emphasis was on global competition and in what way this can influence an establishment’s strategy to boost profits and how to utilize global competition to examine the outcome of relationships among employees and management. These dual topics were fairly straightforward for all team associates to comprehend and might be able to relate to their trades. All team associates were able to convey the topics to their trades and recognize how global competition can influence their specific industry. The topic that we deemed the most affluent with this week was the effect of global competition on an organization’s strategies for maximizing profits. utilizing global competition as a process for maximizing profits is comparatively simple to comprehend because it is simple to see how a business can glance at their competitors internationally to realize where they are deficient or where they are exceling. Benefiting from another businesses marketing strategies or product ideas can help a boost a business’s product sales and can heighten their business. We all concur we should take a step back to see the big picture. Looking at each of our respective trades we often get stuck within the boundaries of our companies. This can limit our abilities to utilize the information gathered from our competition. Examining the result of global competition on the relationship between management and labor was a slight more problematic to understand due to the fact that some employers do not use global competition in order to gauge the relationship between employees and the management group in some of our respective trades. We have never first hand had to use this tool to center on the relationships among employees because the individuals in our departments were hired by Human Resources based upon the circumstance that they understand there will be a good working relationship among everyone. After discussing this issue we as a group find it is important to protect and evolve this relationship between labor and management based on global competition. Sometimes the scale of competition may be between countries, regions, states, or even on much smaller scale cities. Important things we find must not be left out when analyzing this relationship are simple. For example, economics, technology, political, and traditions can lead to a success. Increase wages steadily and keeping benefits for workers is crucial. Working from within to achieve competitive advantages goes hand in hand with improvements for your employees. 3 key points are protecting wages, job security, and benefit gains. Our group now has a better understanding on how global completion can affect companies. This can be in a positive or negative way. Reaching international customers is the main goal. Maintain access to customers, communication, improve service, and the reduction of barriers is very important.

Birth Order and Aggressive Behavior Essay

ABSTRACT The purpose of this research is to determine if birth order correlates to a demonstration of aggressiveness in kindergarten aged children. It is hypothesized that middle born children will demonstrate the most aggressive tendencies, last born children would experience less than the first born, and only children would have the least when compared to all other birth orders. This quasi-experimental methodology will involve a field study of children from the ten kindergarten classes at the Seoul American Elementary School (SAES). Teachers will be asked to complete the Child Behavior Scale (CBS) inventory on each child, used to measure six behavior categories related to aggression. Each CBS inventory will include birth data for the student whose behavior was observed. The findings are expected to show a correlation between birth order and a tendency toward aggression. INTRODUCTION Everyone who is born into a family arrives relative to other children who have already been born or will be at some point in the future or perhaps as an only child. Birth order does not permanently mark each child such as race or gender, but it can impact on the way a person responds to the environment. There have been a number of studies done on the relationship of birth order to personality, intelligence, anxiety and other characteristics with the belief that each child born into a family is treated differently based on their birth order, family interaction and subsequent challenges. Some birth order theorists believe that a child’s position in the family greatly influences their personality characteristics which directly affect their behavior both inside and outside of the home (Morales). Not every theorist has the same view and there are those that believe a psychological birth order has more impact than the physical birth order on the development of personality characteristics (Campbell, White & Stewart, 1991). In his book, Born to Rebel, Frank Sulloway describes how birth order influences our lives in many different ways from achievement to rebellion and from conformity to creativity (The Edge, 1998). While firstborns and laterborns are not much different in overall levels of creativity, the differences in how that creativity is exercised is very different. Firstborns are more likely to win the Nobel Prize by intellectual achievement within the system while the younger siblings will be more inclined to accept radical innovations in science and social though. His findings showed that revolutionaries and those who supported them were disproportionately likely to be later-borns (Sulloway, 1999). While not every social scientist agreed with Sulloway’s research (Harris, 1995; e.g., Falbo, 1997 ), others conducted follow-up studies that confirmed the original findings (Zweigenhaft & Ammon, 2000), and Freese, Powell & Steelman discovered measures in addition to birth order to help explain reasons for various behaviors (1999). This study hopes to build on previous research to determine whether a correlation exists between birth order and a child’s tendency to demonstrate aggressiveness. METHOD Coordination with the Seoul American Elementary School (SAES), a Department of Defense Dependent School located on Yongsan Army Base, Yongsan, Seoul, Korea, will be done to get permission for the study. Permission from the school and the parents of the children selected will be obtained prior to the start of this study. PARTICIPANTS This study will be conducted in the classroom during normal school hours for all students attending the ten full day Kindergarten classes at SAES during a specified 30 day period of the school year. There will be approximately 360 students for this study with an equal number of girls and boys, with 45% of the class comprised of Asian-Americans, 20% African-Americans, 15%  Latin-Americans and the remainder Caucasians. APPARATUS/MATERIALS Teachers will be provided the Child Behavior Scale (CBS) inventory as a means to assess aggressive, prosocial, and withdrawn behaviors of children ages 5-6 years of age. The CBS contains 59 items for which the teacher must respond using a 3-point response scale (1=doesn’t apply, 2=applies sometimes, 3=certainly applies) (Ladd & Profilet, 1996). The CBS measures six categories of behavior as follows: aggressiveness with peers, prosocial behavior with peers, exclusion by peers, asocial behavior with peers, hyperactive-distractible behavior, and anxious-fearful behavior. Copies of the CBS inventory and permission for its use will be obtained from its author, Dr. Gary Ladd, at Arizona State University (an email request has been sent copy of email attached). PROCEDURE Teachers from the 10 Kindergarten classes will observe their students for a specified 30 days during the school year, completing the CBS inventory for each student during that time. The teacher will indicate the birth order of the child on the completed inventory which will then be turned in to the SAES front office to be picked up by the study group. RESULTS The expected results will validate the hypothesis that middle born children will tend to demonstrate more aggressive behavior than either first born, last born or only children. Tables are expected to be used for this study and will include a listing of the CBS subscale items related to firstborn, middleborn, lastborn and onlyborn, further identified by girl and boy. An example follows: DISCUSSION Apart from the effects of birth order, there is little information about the ways in which the nonshared environment influences human development, mainly because psychologists have not been successful in developing direct measures of this environment. The challenge for future researchers lies in devising ways to test competing hypotheses that bear on the nature and influence of this elusive environment. Peer groups are an important aspect of this type of environmental influence, but so is the family environment and life experiences as well (Sulloway, 98). REFERENCES Campbell, L., White, J., & Stewart, A. (1991). The relationship of psychological birth order to actual birth order. Individual Psychology, 47: 380-391. Falbo, T. (1997). To rebel or not to rebel? Is this the birth order question? Contemporary Psychology, 42: 938-939. Freese, J., Powell, B., Steelman, L.C., (1999). Rebel without a cause or effect: birth order and social attitudes. American Sociological Review, 64: 207-231. Harris, Judith Rich. (1995). Where is the child’s environment? A group socialization theory of development. Psychological Review, 102: 458-89. How is Personality Formed? A Talk with Frank J. Sulloway (1998). The Edge Foundation, Inc., Third Culture. Accessed on 13 Feb 2004 at: www.edge.org/3rd_culture/sulloway . Ladd, G. & Profilet, S. (1996). The child behavior scale: A teacher-report measure of young children’s aggressive, withdrawn, and prosocial behaviors. Development Psychololgy, 32 (6), 1008-1024. Morales, C. (1994). Birth Order Theory: A Case for Cooperative Learning. Journal of Instructional Psychology 21: 246-250. Rubin, R. & Hubbard, J. (2003). Children’s verbalizations and cheating behavior during game playing: the role of sociometric status, aggression, and gender. Journal of Abnormal Child Psychology, 31: 65-78. Solo, R., MacLin, M., (2002). Experimental Psychology. Boston: Allyn & Bacon. Sulloway, F. (1999). â€Å"Birth Order† in Runco, M. & Pritzker, eds., Encyclopedia of Creativity, 1:189-202. Zweigenhaft, R., Ammon, J., (2000). Birth Order and Civil Disobedience: A Test of Sulloway’s ‘Born to Rebel’ Hypothesis. Journal of Social Psychology, 140: 624-628.

Essay Free Will Essay

â€Å"Free Will† takes one of the central questions of any religious realm. Whether a human has a freedom in his choice? Whether a human can make a personal, independent decision such us what he should do in each situation? Or are all of his actions predetermined, and the possibility of making a free choice an illusion? Since the time of the Greek philosopher Socrates to modern times, philosophers, theologians, scientists have tried to prove the existence of â€Å"Free Will† or its absence, and as well have to answer to the question do people have real control over their actions? The question, about existence of â€Å"Free Will†, appeared in ancient Greek philosophy. Socrates and his followers believed that the dependence of the lower sensual impulse is an equivalent to slavery, but responsible subordination which was inspired by human mind, means a â€Å"Free Will†. Socrates argued that all humans are looking for the good behavior, but not all equally know what good behavior is. If a person really knows what the true goodness is, then this person wants to do it, but one, who doesn’t know, usually takes imaginary goodness instead of real goodness. Then rushes to reach the imaginary goodness and makes mistakes. This then produces evil deeds. No one is willing to be bad on their own will. This way, moral evil reduced to thoughtlessness, that equal to a lower needs level, and goodness for Socrates, according to Aristotle, expresses of the intellect, which is an equivalent to a â€Å"Free Will†. Which means, only human who doing good things can have â€Å"Free Will†. Based on the foregoing, it is possible to make a conclusion, that by the term â€Å"Free Will†, Socrates understands the qualities that exceptional people have, rather than an integral part of every human being. The idea of â€Å"Free Will† gets a new interpretation with the development of Christianity. If we trace the history of â€Å"Free Will† in the Bible, it is necessary to start with the character of God, who decided on his own and created the universe and all that fills it. The Bible says that man was created in the image and likeness of God. This means that a human is equal to God, and has a consciousness, feelings and will, and has the ability to think and make decisions. Suppose a person is really free in his choice. In such a case, two problems appear right away. According to religious beliefs, everything in this world happens only by the will of God. â€Å"God makes, all he wants, in heaven and on earth. † And no one, including human can’t resist God’s will. How, then, can a person can have any â€Å"Free Will†? If a person is not free, another ethical problem appears. According to Christianity (as well as Islam and Judaism) God rewards man for good behavior and punishes him for his bad. However, if a person cannot choose what he should do in each case, if his actions were predetermined and even corresponded to the will of God, how and why in this case, it is possible to punish humans? And what then is the â€Å"Free Will† for a man? Scientists consider issues related to the freedom of will. With development in science particularly genetic engineering, neuroscience and psychiatry; human view the presence of â€Å"Free Will† has changed. Scientists believe that people do not choose the genotype and the environment, do not choose the other factors affecting their lives. People do not choose in which family to be born, therefore they do not choose hereditary genes that are the most meaningful way determine our lives. Some genes predisposing to a human disease, some genes determining appearance, behavior, intellectual abilities all of them affect our lives. According to scientists, human body is as a kind of machine, established and acting at the direction of the external forces that cause it to work in certain way. This point of view is a concern because it is mean that people cannot be responsible for their behavior in any situation. No one has found the answer to the question of whether people have the â€Å"Free Will† or is it just an illusion. But in any case, a human has the right to follow the path of good or choice the path of evil. All humans exist like cells in a single large organism called â€Å"the universe. † World created from all its parts or elements. Each element contributes to the world their personal characteristic; effects and change world’s destiny. It may be weak and insignificant in the overall system of the world, but it is exists. It operates within certain limits on domestic fundamentals essence and nature. Without any of these elements would be a different world.

Summary of support group meeting that focuses on mental health needs, Assignment

Summary of support group meeting that focuses on mental health needs, eg. depression etc - Assignment Example In a situation where she would not manage to access it, she had to go home or eat whatever was available, but the desire to eat would height. The worst problem was that she only craved for junks, a situation that resulted in uncontrolled weight gained, which made it very difficult for her to walk for long distances, run or even participate in activities that required physical strength. The meeting had eight members and each individual had a different story to share concerning their eating disorder, and how their families were tirelessly seeking ways through which they would help them solve the problem. I felt a sense of belonging, because I was among individuals that completely comprehended what I was going through and they were willing to share and engage each one of us in finding a solution to the problem that we were facing. I thought for a while, why it took so long to join the group, but I realized as most other members revealed that I lived in denial that I did not have a problem. I feel grateful to the people that encouraged me to take the step of engaging in the group therapy, because it helped me deal with the problem of isolation and stereotype that people who did not understand what I was going through displayed. As Halter and Varcarolis (2014) assert, group therapy offers quality ground on which people facing a similar issue can share their experiences and strategize ways to deal with the

Quantitative Portfolio Management - Homework 1 Case Study

Quantitative Portfolio Management - Homework 1 - Case Study Example From the graph, Roy (1952) argued that investors should pick portfolios in order to maximize the likelihood of getting above some threshold minimum return.. Drawing a straight line from this minimum return tangent to the efficient frontier. Lower thresholds result in optimal portfolios with less return / risk, once you have identified the efficient frontier Using the idea that risks come from different sources, a â€Å"single index model† assumes that actual returns can be separated into systematic (i.e. market-related) and firm-specific parts †¦ here, the â€Å"market† (e.g. S&P500 index) is the source of market-related movements in security i: Since there is no perfect match for this assets, that various portfolio combinations of most two-asset portfolios will lie on a curve to the left as you reduce correlation between pairs of assets, you will have to risk for a given level of portfolio return. Result: One portfolio (P) dominates all of the other efficient portfolio on the efficient set Investors who choose combinations of P and the risk-free asset get the highest return for a given level of risk, compared to all other risky

Dunkin Group INC Research Paper Example | Topics and Well Written Essays - 1250 words

Dunkin Group INC - Research Paper Example Customers are able to enjoy services in Philippines, Guatemala and over other regions. The organization has been able to meet the demand of these markets due to some strength in their operation. It has been able to meet its customers tastes by providing it quality products. Its communication network has made it easier for the franchise to meet various customers requests. In respects to it products, since inception the franchise manages two units. One of its units refers to the Dunkin donut branch. The other branch relates to its branches representing Basken-Robbins operational unit. For the last 120 years, Dunkin donut unit has been providing restaurant like services to customers. It concentrates in providing products such as muffin, bagel donut and coffee. Basken Robbins on the other hand specializes in refrigerated products. This franchise has been instrumental in providing ice cream products. Dunkin Donuts has over 11000 branches all over the globe. The franchise further branches in 33 countries. It is also imperative to note that the franchise has the capacity of making up to $7billion. Dunkin brand Inc has two subsidiary branches all over the market. The firms income as in the year 2011 was $ 34.442 its revenue was $628.198 in that year. On the other hand, its total assets as at the end of that year were at$3.2224 billion. The mission of Dunkin Inc is to provide services and products to the community. The organization conducts this function by ensuring that the basic need of the society comes to fulfillment. The firm provides products for the hungry under partnership with other organization. Some of the organizations that collaborate with the franchise include those organizations providing relief food items. Moreover, it is part of the organizations agenda to provide safety to the community. Dunkin Inc provides these services through partnerships. The organization collaborates with troops, firefighters and other security service providing

Biomedicine Essay Example | Topics and Well Written Essays - 1500 words

Biomedicine - Essay Example Source en.wikipedia.org/wiki/Biomedicine The basic underlying principle of the health care system is to treat disease on the basis of diagnoses arrived at by using symptoms and investigations. However, the effectiveness of treatment based on this rationale has been questioned. This process, which often overlooks patients' specific environments, everyday experiences, social conditions and the external environment, has been reviewed with a different angle. During the last few decades, there has been much criticism associated with this rationale. A number of 'new' concepts have been introduced in the medical discussions, such as illness, health, life quality and function. This has heralded a need for change in the everyday practices of parts of the health care system. This healthcare system that consists of general practitioners, public health personnel, nurses and paramedics has been changing so subtly, that it has not kept pace with the momentum of change in the medical arena made more complex by the population explosion and healthcare issues. This is especially true of the initial diagnostic visits between the patient and the doctor where the primary encounters occur. This is also ripe for change in the preventive health care segment where a lot of earlier sidelined concepts have now started to emerge. Recently, concepts of health and illness have been changing from before. The comprehension of health and illness has been changing due to input fuelled by perspectives from many disciplines. Health has now become a more holistic concept and has benefited by the increasing acknowledgement of other sources like biology, environment, social position, and the role of the mind, culture, spirituality, race, and sex, that influence health and well bein g. These have served to widen the realm of focus on the issues of health and illness. The health care systems are now more of a social model of health and this could explain the reasons for the increasing use of alternative therapies such as homeopathy, natural healing methods, acupuncture etc. Last, but not the least, stress has been accepted to be a major causative factor, and prevention and stress management methods seem to be a great approach to managing health proactively. This creates more focus on prevention than cure and more reasons to treat the causative factors rather than the symptoms of the disease. The main influences that have initiated a need for the reformulation of biomedicine may be attributed to a number of causes, some of which have been discussed as follows. Rising costs of health care are not matched by corresponding gains in population health; in particular health inequalities seem to take an upward trend. (Hallam, 2003) Managed health care has become so commercialised that it has become a luxury rather than basic need to be able to access medical care when essential. Modern investigative medical tests and treatments are expensive, rendering it unaffordable to a lot of people in the society. Individuals are bereft when they are unable to afford the huge insurance premiums, especially, the lower socio economic groups. This results in postponement of a visit to the doctor until really chronic, thereby not only missing opportunities to diagnose serious illnesses earlier than later but adding to the burden of the healthcare system by the extensive treatment that would now be required. Since

Media Artifact Analysis Paper Research Example | Topics and Well Written Essays - 2000 words

Media Artifact Analysis - Research Paper Example ital media is becoming more complicated because is teaching today’s generation how to live entirely depending on virtual reality which is associated with time-saving simulation of actual real experience that enable to face time with genuine people (Berger, 2012). As a child everybody remembers spending a lot of time in front of a television and all over sudden your parent comes from nowhere yelling at you sending you outside to play with other kids. The reason behind this was to discourage you get addicted to the television but go outside and have fun as you have real life experience with other kids. This experience helped as to have a chance of interacting and learning from others as we socialize (Ball & Helbing, 2012). The twoube with Twitters is now a trend parody of a current popular online social networking application known as Twitter. This application enables an individual to update their status and activities constantly anytime they feel like throughout the day. When it was first discovered and came into the scene in 2006 after some few years of getting ready the site has cemented following and became home for many global chatter. With the modern culture where convenience is key, the dependence on Twitter is high from the television all the way to billboards, it has proved to be a free platform for marketing of all kind of business, it provides people with an opportunity to always keep in touch anywhere with friends and families, and therefore, Twitter gives something for everyone. The main condition while using Twitter is to within its limit of about 140 characters when posting your massages. The massages or as they are known as â€Å"tweets† being the language used are posted regularly on Twitter’s timeline in real time, here is where tweets originating from followers are contained although there are a number of Twitter’s applications that an individual can download for both cell phones as well as computers (Dijck, 2013). The following are the

Sociology Paper Essay Example | Topics and Well Written Essays - 750 words

Sociology Paper - Essay Example In the reading, â€Å"making sense of the senseless: understanding genocide†, the authors begin with a statement that solidifies their greater purpose. That is, â€Å"all genocides are horrific, but not all genocides are the same. they can arise from cold-blooded calculations, realistic fears instincts for revenge, or ideologies of purification. understanding-and perhaps forestalling- genocide requires clear distinctions,† (Chirot & Edwards, p.406). A clear distinction to be made would be that, while genocide and the wars that come about are horrid, their root causes can differ to varying degrees, by what caused them in the first place. The inner meaning of the text, as written by Daniel Chirot and Jennifer Edwards, is to consider the frightening human atrocities of such events as the ethnic cleansing in Yugoslavia in the 1990s, as well as the extermination of the Jewish people during World War II, along with Rwanda, but to look at them through the means in which they were initiated. â€Å"The inevitable comparisons of these recent atrocities to those of the past, most notably the Holocaust, are highly controversial. Classifying an event as a genocide can be used to legitimate the claims of survivors or as justification for reprisals against perpetrators. Therefore, several questions about genocide should be considered: (1) How successful does an attempted â€Å"cleansing† of a group need to be to warrant classification as genocide? (2) Does a certain number or percentage of a population need to be killed? (3) Does the intent of the perpetrators make any difference? (4) Should the term genocide be reserved for the murder and expulsion of religious or ethnic minority groups or can political dissidents or enemies in war be victims of genocide?† (Chirot & Edwards, p.406). The subjective facts listed within the article would be the tendency of many to want to classify any form of

Cash flow analysis Essay Example | Topics and Well Written Essays - 3750 words

Cash flow analysis - Essay Example The company sells its products online and also through merchants. Other products and services the company provides are; server and storage software, Microsoft Dynamics and video game consoles. It’s also involved in mobile software production; recently they purchased Nokia Handset Business. Without doubt the Microsoft company is one among the leading companies in its industry. A common size financial statement shows all items as percentages; this enables easy analysis over a given time. A common analysis from 2011 to 2014 was made. This analysis illustrated a decrease in the profits made over those three years. On the other hand an increase in the cost of sales over this period was observed. The operating cost remained the same over this period of time. The provision of 7% total sales was constant. The net income as in june 2014 was 25.42% which was a decrease, in 2013 net income was 28%, 2012 was 23%, while 2011 was 33%. A statement for the those three years tells us that cash and cash equivalents ant the current assets have increased slowly over time. On a different observation for the same period, there was a decline in terms of the long term assets of the company related to the decline in goodwill. In 2011 to 2014 the current and long term liabilities have held constant. There has been a decline from 47 to 44% in the total liabilities of the company w hile the stockholders’s equity has increased over that period from 52 to 55%. The financial statement provides information regarding the prospect earnings capacity of a corpoartion’s assets over and above an indication of cash flows which might come from inventories and receivables . the figures in the table is in USD $ in millions and was adopted from Microsoft Corporation, the annual reports Ratio analysis for this period was done to get an indication of the company’s financial performance in

Financial accounting Essay Example | Topics and Well Written Essays - 1250 words

Financial accounting - Essay Example It is headquartered at Dearborn, Michigan, USA. The company has remained under family ownership ever since (Bender, Slade, and Thorpe, 2009, p. 4). Ford Motor conducts its business in two different business segments namely, automotives and financial services sector. This report entails about the assets utilised by the company to carry on its business activities. This report also analyses the technological and other means through which the organisation generates revenue out of its assets. The process of asset valuation used by Ford Motors has also been included in this study. Finally the various sources of funds utilised by the company to conduct its operational activities have been discussed in this study. Assets The consolidated balance sheet of Ford Motors Company includes various types of assets owned by the company. Some of those items are: cash and cash equivalents, marketable securities, finance receivables, investment in operating leases, inventories, property, deferred income taxes and intangible assets. As at 31 December 2011, Ford Motors had $18,618 million as marketable securities (Ford Motor Co., 2012). Marketable securities are a form of assets which helps in storing excess cash that can help to generate return for the company (Fabozzi, and Peterson, 2003, p. 645). Ford Motors is found to have invested in the marketable securities of automotive and financial services sector. Total assets of the company in the form of investment in operating leases were $12,838 million as on 31 December 2012 (Ford Motor Co., 2012, p. FS-4). Those operating leases mostly consisted of lease contracts for vehicles with all its different types of existing customers. Accounts receivables are mainly in the form of finance receivables which amounted to $69,976 million as at 31 December 2011. Other receivables amounted to $8,565 million (Ford Motor Co., 2012, FS-4). The finance receivables correspond to the automotive and financial services sector. The notes receivables in the automotive sector are primarily related to the purpose of restructuring the businesses of the company and loans with the suppliers. Ford Motor Credit Company LLC which is a wholly owned subsidiary of Ford motors offers different types of automotive financing products all around the world. Ford Credit's business activities mostly consist of supporting its dealers and financing the vehicles. This results in a large portfolio of leases and finance receivables for the company. The total inventories of the company as at 31 December 2011 were $5,901 million (Ford Motor Co., 2012, FS-4). The inventories of the company consisted of raw materials, work-in-process and supplies which amounted to $2,847 million at the end of the financial year 2011. The finished products amounted to $3,982 million and total inventory is calculated as $5,901 million after adjusting on the basis of (Last in First Out) LIFO. Thus the inventories of Ford motors are lean in nature because they follow the build t o order strategy (Ford Motor Co., 2012, FS-38). The inventories of the company which is primarily the service part obsolescence amounted to an ending balance of $249 million as at 31 December 2012 (Ford Motor Co., 2012, p. FSS-1). Use of Technology and Revenue Generation Revenues are recognised by the companies in United States mostly in accordance with the US GAAP (Nikolai, Bazley, and Jones, 2009, p. 931). Revenues from the automotive business segment of Ford Motors are generally generated through sales of automobiles and its accessories. Revenues are recorded in the books of account of the company only after the risks and rewards of ownership related to the products are completely transferred to its

Curriculum designing guidelines Essay Example for Free

Curriculum designing guidelines Essay Purpose The construction of experiences and outcomes that effectively provide progression in each curriculum area and convey the values, principles and purposes of A Curriculum for Excellence is central to the success of the program. In particular, it is important that you reflect relevant aspects of the four capacities in your work. If we can get this right these outcomes and experiences will have a significant, positive, impact on classroom practice and hence on the learning experience of all children and young people. It is an exciting prospect. Starting point In phase 1 each early review group should be asked to simplify and prioritise the curriculum (from age 3 to 15 in the first instance) retaining what currently works well and making changes where these were justified by research evidence. The output from phase 1 of the review process and the rationale for your curriculum area, research and other national and international comparators are your starting points. Your work will be based on the relevant parts of the Curriculum Frameworks: for Children 3 – 5, 5 – 14 guidelines, Standard Grade, and National Qualifications. It is important that experience and outcome statements you write at each Curriculum for Excellence level provide appropriate cognitive demand. The framework for outcomes The experiences and outcomes will sit within a framework of advice to teachers. Curriculum Area The eight curriculum areas are: Expressive Arts, Health and Wellbeing, Languages, Maths, Religious and Moral Education, Science, Social Studies and Technologies. Rationale The rationale provides an overview of the curriculum area states its main purposes and describes its contribution to the values and purposes. Subsets of the curriculum area Each curriculum area is subdivided either into fields of learning – or ‘subjects’ (e. g. Expressive Arts into art, drama, dance and music) or into aspects of learning in that area (e. g. Languages into listening and talking, reading and writing) Lines of development These identify learning tracks in each subset of the curriculum area. They are expressed in different ways in each area of the curriculum. For example within expressive arts they identify the skills to be developed: creating, presenting and evaluating in art, drama, dance and music; within science they describe broad areas of knowledge and understanding to be developed; biodiversity, being human and cells in Our Living World. Experiences and outcomes Within each line of development, experiences and outcomes describe the expected progression in learning for children and young people. Essential outcomes. Essential outcomes are a small number of high level statements, derived from the main purposes described in the rationale, that encapsulate what learning in that curriculum area provides for all children and young people. Taken together, the essential outcomes are intended to sum up the expectations for the broad general education of all young people. The focus of your work will be writing the experiences and outcomes for your curriculum area. It is likely that there will be interplay between what you produce and the ‘essential outcomes’ , which are the ones helping to shape and refine the other in an iterative manner. Outcomes should be written in the clearest possible English. Where possible these should be accessible to children and young people, but not at the expense of clarity. It is also important to try to write lively and engaging experiences and outcomes. Best Practices of Writing the Curriculum Ultimately the intention is to produce streamlined guidance for the entire curriculum in a single document. We also intend to make the outcomes available in electronic format to allow curriculum leaders and teachers to identify and blend outcomes from both within and beyond curriculum areas. Several stages will be required to achieve this.

Economies of Scale Economies of Scope in long run

Economies of Scale Economies of Scope in long run Paridhi Gupta Introduction Economies all about cost effectiveness. The term Scale is all about the benefits gained by the production of large volume of a product. The term scope is linked to the benefits gained by producing a wide variety of products by efficiently utilizing to same operations. What are Economies of Scale? The term economies of scale refers to a situation where the cost of producing one unit of a good or service decreases as the volume of production increases. Economies of scale arise when the cost per unit falls as output increases. Economies of scale are the main advantage of increasing the scale of production. Examples:- Table 1 Assume each unit of capital = Rs.5, Land = Rs.8 and Labour = Rs.2 Calculate TC and then AC for the two different ‘scales’ (‘sizes’) of production facility AC = TC / Q TABLE 2 Doubling the scale of production (a rise of 100%) has led to an increase in output of 200% therefore cost of production PER UNIT has fallen Don’t get confused between Total Cost and Average Cost Overall ‘costs’ will rise but unit costs can fall Classification of Economies of Scale: Marshall made a differentiating concepts of internal and external economies of scale. That is that when costs of input factors of production go down, it is a positive externality for all the firms in the market place, outside the control of any of the firms. Internal Economies of Scale Internal economies of scale relate to the lower unit costs a single firm can obtain by growing in size itself. This means that the internal economies are exclusively available to the expanding firm. Internal economies of scale may be classified under the following categories. Bulk- buying economies As businesses grow they need to order larger quantities of production inputs. For example, they will more raw materials. As the order value increases, a business obtains more bargaining power with suppliers. It may be able to obtain discounts and lower prices for the raw materials. Technical economies Businesses with large-scale production can use more advanced machinery (or use existing machinery more efficiently). This may include using mass production techniques, which are a more efficient form of production. A larger firm can also afford to invest more in research and development. Financial economies Many small businesses find it hard to obtain finance and when they do obtain it, the cost of the finance is often quite high. This is because small businesses are perceived as being riskier than larger businesses that have developed a good track record. Larger firms therefore find it easier to find potential lenders and to raise money at lower interest rates. Marketing economies Economies in marketing arise from the large –scale purchase of raw materials and other material inputs and large scale selling of the firm’s own product. Every part of marketing has a cost – particularly promotional methods such as advertising and running a sales force. Many of these marketing costs are fixed costs and so as a business gets larger, it is able to spread the cost of marketing over a wider range of products and sales – cutting the average marketing cost per unit. Managerial economies As a firm grows, there is greater potential for managers to specialise in particular tasks (e.g. marketing, human resource management, finance). Specialist managers are likely to be more efficient as they possess a high level of expertise, experience and qualifications compared to one person in a smaller firm trying to perform all of these roles. External economies of scale External economies of scale occur when a firm benefits from lower unit costs as a result of the whole industry growing in size. External economies accrue to the expanding firms from advantages arising outside the firm e.g. in the input markets. The main types are: Transport and communication As an industry establishes itself and grows in a particular region, it is likely that the government will provide better transport and communication links to improve accessibility to the region. This will lower transport costs for firms in the area as journey times are reduced and also attract more potential customers. For example, an area of Scotland known as Silicon Glen has attracted many high-tech firms and as a result improved air and road links have been built in the region. Training and education becomes more focused on the industry Universities and colleges will offer more courses suitable for a career in the industry which has become dominant in a region or nationally. For example, there are many more IT courses at being offered at colleges as the whole IT industry in the UK has developed recently. This means firms can benefit from having a larger pool of appropriately skilled workers to recruit from. Other industries grow to support this industry A network of suppliers or support industries may grow in size and/or locate close to the main industry. This means a firm has a greater chance of finding a high quality yet affordable supplier close to their site. The long run average cost curve (LRAC) The long run average cost curve (LRAC) is known as the ‘envelope curve’ and is usually drawn on the assumption of their being an infinite number of plant sizes – hence its smooth appearance in the next diagram below. The points of tangency between LRAC and SRAC curves do not occur at the minimum points of the SRAC curves except at the point where the minimum efficient scale (MES) is achieved. If LRAC is falling when output is increasing then the firm is experiencing economies of scale. For example a doubling of factor inputs might lead to a more than doubling of output. Economies of scope Economies of scope is a term that refers to the reduction of per-unit costs through the production of a wider variety of goods or services. Many firms produce more than one product. Sometimes, a firm’s products are closely linkes to one another. An automobile company, for instance, produces automobiles and trucks, a chicken farm produces poultry and eggs. At other times, firms produce physically unrelated products. In both caes, however, a firm is likely to enjoy production or cost advantages when it produces two or more products. These advantages could result from the joint use of inputs or production facilities, joint marketing programs, or possibly the cost savings of a common administration. Example of Economies of Scope McDonalds can produce both hamburgers and French fries at a lower average cost than what it would cost two separate firms to produce the same goods. This is because McDonalds hamburgers and French fries share the use of food storage, preparation facilities, and so forth during production. Difference between economies of scale and economies of scope Mergers and Acquisitions Mergers are basically combining of two business entities under common ownership. Two companies legally become one. All assets and liabilities being merged out of existence become assets and liabilities of surviving company. Under acquisitions one firm buys the assets or shares of another. Acquired company becomes subsidiary of purchasing company. Different Types of Mergers A horizontal merger This kind of merger exists between two companies who compete in the same industry segment. A vertical merger Vertical merger is a kind in which two or more companies in the same industry but in different fields combine together in business. Co-generic mergers Co-generic merger is a kind in which two or more companies in association are some way or the other related to the production processes, business markets, or basic required technologies. Conglomerate Mergers Conglomerate merger is a kind of venture in which two or more companies belonging to different industrial sectors combine their operations Different Types of acquisitions Friendly acquisition Both the companies approve of the acquisition under friendly terms. Reverse acquisition A private company takes over a public company. Back flip acquisition- A very rare case of acquisition in which, the purchasing company becomes a subsidiary of the purchased company. Hostile acquisition Here, as the name suggests, the entire process is done by force. Motives for Mergers Acquisitions Economies of large scale business large scale business organization enjoys both internal and external economies. Elimination of competition It eliminates severe, intense and wasteful expenditure by different competing organizations. Desire to enjoy monopoly power MA leads to monopolistic control in the market. Adoption of modern technology corporate organization requires large resources Lack of technical and managerial talent Industrialization, scarcity of entrepreneurial, managerial and technical talent Creation of Synergies The financial benefit that two companies may derive from a merger or acquisition is called synergy. The synergistic effect may also refer to the cost reduction a merger brings about by eliminating or streamlining redundant processes. Different types of Synergies enjoyed through MA Management Synergy Management synergy refers that the companies use its extensive and efficient management resources through new permutations and combinations after MA to improve the existing management and finally increase the revenue. Operating Synergy Operating synergy refers to the improvement of production and operation efficiency of enterprises which caused by economies of scale and economy of scope after MA. Financial Synergy Financial synergy refers to the financial benefits generated by MA transaction. It is a net cash flow on benefits which are caused by tax laws, accounting standards and other provisions of the securities and exchange. Production Synergy Two companies that merge may be able to produce more revenue than either one could produce independently by combining the most efficient processes each brings to the merger. Risks Analysis of the Realization of Synergistic Effect The risks of the realization of synergistic effect refers to the uncertainty of the increment of corporation value and the performance of strategic MA. Such risks always exist throughout the whole process of synergistic effect realization. From the view of the root causes of the risks, such risks can be divided into internal risks and external risks Internal Risks Internal risks mainly refer to the synergistic effect of risks which is caused by MA transactions and integration. Synergistic effect of internal risks mainly includes financial risk integration risk anti-MA risk principal-agent risk asymmetric information risk 1) Financial risk. MA often requires large amounts of capital, how to raise funds in short term is very important. Companies can use cash, stock or debt financing for the MA. Either way, there are great risks. If companies use cash to complete the MA, there will have the following short-comings: first of all, a one-time large amount of cash outflow for MA will cause intense pressure on the production and management of the enterprise. Second, the trade size will be restricted by the ability to obtain cash and lead to the failure of a large-scale MA. Moreover, the merged side may not like cash payment, because they cannot get the new company’s equity, this situation will also lead to MA risks. 2) Integration risk. According to a survey on the failure of MA, about 80% of MA failures are caused by enterprise integration failures. The MA integration risk is manifested mainly in the following three aspects: first, production and technology cannot achieve the expected synergy after MA. For example, the MA side usually wants to implement diversification through MA so as to enter new areas, when the growth of the new areas are faced with obstacles, it often makes MA activities in trouble. Second, the integration of personnel, institution and culture after MA. If the enterprise cannot make effective integration according to the designed MA plan, this will lead to the conflict of personnel, institution and cultural be-tween new and old enterprises and resulting in internal friction. Third, the impact of MA on business relationships, such as the impact on customers and suppliers. MA might cause deterioration in external business relationship and lose some customers and suppliers, thus lead to the increa se of enterprise’s operating costs and reduction its profitability. 3) Anti-MA risk Under normal circumstances, the merged enterprise’s attitude of MA is uncooperative. Because the merged enterprises are usually inferior enterprises, they will find ways to stop MA. Such practices will greatly increase the MA risks. In addition, under the modern corporate governance structure, a successful MA must first be accepted by enterprise management, then adopted by the board of directors in the enterprise, at last obtain the consent of the large, small and medium-sized investors. 4) Principal-agent risk For pursuing business expansion, the senior executives with information superiority might ignore the interests of shareholders to meet the needs of their individual fame and fortune. The â€Å"out of control† risk of principal-agent relationship in MA decision is very dangerous. In a company, the relationship between its manager and corporate owners is principal-agent relationship. The company management might pursuit company expansion for their own interests to show their performance. They have information superiority and might agree on the unreasonable terms of the target company without considering its own financial and operating conditions. This conduct will increase the realization cost of synergy and reduced synergy benefits. 5) Asymmetric information risk In the market mechanism of incomplete competition, the problem of information asymmetry is quite general. During the course of strong company’s acquisition of target company, the target company’s executives might conceal the facts such as enterprise’s hidden losses of contingent liability and the true value of patents to achieve their private intentions. They might also collude with the agency or the insider of the strong enterprise to make false information so that the policy makers of the merging side might make wrong decisions. External Risks As synergistic effect is based on certain of development strategy and the formulation of such a development strategy is based on external environment, therefore, the changes in external environment not only affects the enterprise’s development strategy, but also cause the deviation from the expected synergies. The external risks of synergistic effect mainly include policy risk legal risk industrial risk. 1) Policy risk. Policy risk refers to the synergy risk which caused by the adjustment of national economic policies. The government develops special policies to protect the vested interests of government and â€Å"special groups† or uses administrative means to arbitrarily change its policy to destroy the normal order of market competition, such behavior would increase the risk of synergy. 2) Legal risk. Legal risk mainly lies in the following three aspects. The first is the provisions of anti-monopoly law. Most of western countries developed a series of anti-monopoly laws to safeguard fair competition. The second is the specific provisions of MA in the law. For instance, according to the correlated laws, if the acquirer holds 5% of a listed company’s shares, it must notice and suspend trading, for each 2% subsequent increment, it is necessary to repeat the process, if holding 30% of the shares, it must launch a comprehensive tender offer. This provision leads to great increase of the acquisition costs and MA risk. Thirdly, during the course of MA, as laws and regulations are incomplete, the conduct of company cannot be guided correctly, thus result in the increase of MA risk. 3) Industrial risk. Industry risk refers to the uncertainty of the industry prospects caused by the changes of country’s economic situation and industrial policy, which might influence the enterprise development strategy. In the process of MA decision-making, many enterprises sink into woeful situation because they are not familiar with the new industry they wish to enter or without a accurate grasp of the industry prospects. The â€Å"big diving† of e-commerce enterprises in the last two years are good examples. Conclusion Bibliography http://tutor2u.net/economics/content/essentials/economies_scale_scope.htm http://www.tutor2u.net/business/gcse/downloads/production_economies_of_scale.pdf www.scirp.org/journal/PaperDownload.aspx?paperID=4385 Pindyck, Rubinfield, Mehta, MicroEconomics, 7th Edition, Pearson

Role of Omega-3 and Vitamin B6 in Cancer Prevention

Role of Omega-3 and Vitamin B6 in Cancer Prevention A critical analysis of the role of omega-3 and vitamin B6 in cancer prevention: current evidence, proposed mechanisms and future directions Abstract: A critical analysis of the role of omega-3 and vitamin B6 in cancer prevention: current evidence, proposed mechanisms and future directions Cancer is a leading cause of death worldwide and according to the World Health Organization(WHO accounted for 8.2 million deaths in 2012(1). The complex and dynamic nature of cancer is evident, however 30% of cancers could be prevented by modifying factors such as diet, not smoking, physical activity and moderate use of alcohol(2). Scientific evidence suggests that nutritional supplementation of some nutrients can affect the risk of different cancers. For the purposive of this essay I will perform a critical analysis of the role of omega-3 and vitamin B6 in cancer prevention by reviewing the current evidence, proposed mechanisms and investigating the future directions of omega-3 and vitamin B6 use in cancer prevention. Omega-3(n-3) and omega-6(n-6) polyunsaturated fatty acids(PUFAs) are essential fatty acids that cannot be made by the human body and therefore must be obtained from the diet. The use of n-3 PUFAs in a number of chronic diseases such as coronary artery disease, psoriasis, irritable bowel syndrome and rheumatoid arteritis has been associated with health benefits. Increasing evidence from animal and in vitro studies indicate that n-3 PUFAs, especially eicosapentaenoic acid (EPA) and docosahexaenoic(DHA) acid play a role in inhibiting cancer progression(3). However epidemiological data on the association between n-3 PUFA intake and cancer risk appears to be somewhat less consistent. High fat intake, typically seen in western diets is associated with an increased risk for cancer development. N-3 PUFAs are an exception as studies have found that n-3 PUFAs have protective functions in prostate, pancreatic, breast and colon cancer. Western diets typically contain a high n-6 to n-3 ratio which has been found is positively associated with prostate cancer development. A study carried out in Jamaican men who had a high ratio of dietary n-6 to n-3 ratio, found that n-6 PUFAs was positively correlated with prostate carcinogenesis while n-3 PUFAs inhibited cancer growth(4). In agreement with this study a case control study of 79 prostate cancer cases and 187 controls, found a high ratio of n-6 to n-3 PUFAs increased the overall risk of prostate cancer in white men and possibly increase the risk of a high grade prostate cancer in all men(5). Population based studies have found that the use of n-3 PUFAs are protective against cancer development. A population based prospective cohort study of 90,296 subjects found that a diet rich in n-3 fish or n-3 PUFA appeared to protect against the development of hepatocellular carcinoma (6). In agreement with this study a population-based prospective study in Japan found an inverse relationship between n-3 PUFA intake and the risk of cancer in the proximal site of the large bowel(7). However not all studies have found beneficial effects of the use of n-3 PUFAs in cancer prevention. A French study comprising of over 56,000 women, who were followed for eight years found no associated between n-3 PUFA and breast cancer risk(8). Numerous mechanisms have been proposed for the beneficial effects of n-3 PUFAs in cancer prevention. PUFAs are capable of influencing the fatty acid composition of glycerophospholipids in cell membranes. N-3 PUFAs can replace n-6 PUFAs in glycerophospholipids(9) and a high n-3 to n-6 ratio has been found to affect cell membrane signalling. Lipid rafts are important signalling domains within the cell membrane which contain receptors such as epidermal growth factor receptor(10). As DHA has a poor affinity for cholesterol in lipid rafts it can supress raft associated signal transduction(10). This is important as in many cancers signalling pathways can be over activated. It has also been suggested that n-3 PUFAs may induce apoptosis and reduce proliferation in human cancer cells by decreasing signalling through AKT/NFkB and by modulating the PI3k/AKT/p38 MAPK pathway(11). N-3 PUFAs are involved in the suppression of arachadonic acid (4n-6) derived eicosanoids, which are involved in cellular growth, cell differentiation and have proinflammatory effects (12). Arachadonic derived eicosanoids such as PGE2, have been positively linked to cancer (13), unlike EPA eicosanoids which have anticancer effects(14). As mentioned above incorporation of n-3 PUFAs into the phospholipid membrane replaces n-6 arachadonic acid precursors, decreasing arachadonic derived eicosanoids and increasing EPA eicosanoids. N-3 PUFAs have also been found to supress cyclooxygenase-2 (15), which has anti-tumour affects as COX-2 down regulates apoptotic pathways(16). This is in contrast to n-6 PUFAs which have been found to upregulate COX-2(17). It is also interesting to note that in breast, colon and prostate cancer COX-2 is overexpressed (18, 19). Taking this into account it is likely that suppression of COX-2 by n-3 PUFAs may be a preventative measure in these cancers. In conclusion there is evidence for the beneficial effects of n-3 PUFAs in cancer prevention, however due to inconsistencies in epidemiological data it is too early to recommend the use of n-3 PUFAs for cancer prevention. Possible explanations to explain these inconsistencies may be that population-based studies rely heavily on data from self-reported dietary PUFA intake. This form of data collection may poorly correlate with accurate PUFA intake. Another possible explanation is that the amount of n-3 PUFA administered in studies, may not be of a sufficient quantity to have a protective functions in cancer prevention. Further studies are needed to be carried out to account for the current variation in published studies before recommending n-3 PUFAs for cancer prevention. According to the latest report from the National Cancer Registry: Colorectal cancer (CRC) is the second most common cancer in both men and women in Ireland (20). Environmental factors such as diet have been identified as playing a role in the risk of CRC development. Preventability estimates from the World Cancer Research Fund show that 47% of cases of CRC in the UK can be prevented by modifying factors such as eating and drinking healthily, being physically active and maintaining a healthy weight(21). According to the National Health and Nutrition Examination Survey 2003-2004 24% of people (who did not take supplements containing vitamin B6) have suboptimal active B6 plasma concentrations (22). Vitamin B6 is a water soluble vitamin, which in its active form: pyridoxal 5’-phostphate (PIP) is involved in more than 100 coenzyme reactions, including lipid, carbohydrate and protein metabolism(23). Vitamin B6 may play a role in CRC prevention through its role in one carbon related DNA synthesis and methylation(24). Vitamin B6 has also been shown to reduce the formation of nitric oxide(25), inhibit angiogenesis(26) and reduce oxidative stress(27), creating an unfavourable environment for tumour development. Despite the mechanistic evidence supporting for the role of vitamin B6 in CRC cancer prevention, epidemiological evidence has been inconsistent. A meta-analysis of 9 studies carried out between 2002-2009 on Vitamin B6 intake in relation to CRC risk, found inconsistent results with both an inverse and positive association(28). The same meta-analysis included four nestled case-control studies investigating serum PLP on CRC risk. All four studies found an inverse relationship between PLP levels and CRC risk, with an overall reduced risk of CRC for every 100-pmol/mL increase in serum PLP(28). In the 9 studies of vitamin B6 intake and CRC risk it seems that highest vs lowest category of vitamin B6 intake was most important. When the study’s results were pooled together, a 21% significant reduction in CRC risk was found when comparing high vs low vitamin B6 intake in studies with a wider range of exposure (>1.5-mg difference)(28). A different study prospectively followed up 26,440 women and 44,410 men to assess whether a higher vitamin B6 intake in the remote past(12-16years prior to diagnosis) was more strongly associated with a lower risk of developing CRC than an intake in the recent past (4 years prior to diagnosis)(23). The results of this study did not support a strong role of vitamin B6 intake in preventing CRC development. However most of the participants were relatively well nourished, with only 5-10% of people having a vitamin B6 intake below the recommended daily allowance(23). This limited the study as it is not the most accurate measures of determining the potential effects on suboptimal vitamin B6 on CRC risk. The Japan Public Health Centre-based Prospective study investigated the association of dietary folate, vitamin B6, vitamin B12 and methionine on CRC risk(29). The study included 81,184 participants (38,107 men and 43,077 women) who were followed from 1995-98 to the end of 2002. A significantly inverse relationship between vitamin B6 intake and CRC was found in men. Men in the highest quartile of vitamin B6 intake had a 35% decreased risk of CRC compared with men in the lowest quartile. No association was found in vitamin B6 intake and CRC in women. Interestingly a higher intake of vitamin B6 appeared to be beneficial in men with higher alcohol intake. The study found that the risk of CRC associated with alcohol intake was significantly higher in those who had a low vitamin B6 intake, however this risk was found to decrease in those who had a higher vitamin B6 intake(29). In conclusion there is evidence to suggest that vitamin B6 may play a role in CRC prevention, however it appears that plasma PLP appears to be more strongly linked to a reduced risk in CRC. Studies investigating the effect of vitamin B6 intake on CRC risk appear to be inconsistent. In contrast studies on PLP have found higher plasma PLP CRC risk by 30-50%(23). It is also important to note that studies have found that individuals with higher activity levels, higher dietary intakes of folate and calcium and individuals who do not smoke have higher vitamin B6 levels and a decreased risk of CRC(23). In these individuals it is difficult to determine if it is these healthier behaviours or the increased B6 levels that decreases CRC risk. It is also difficult to assess the impact of dietary vitamin B6 on its own on CRC risk, as most foods containing vitamin B6 contain various other nutrients such as folate and vitamin D. Further studies are needed to be carried out to explain the current inconsistencies in the use of vitamin B6 and CRC risk before vitamin B6 can be recommended as a preventive measure. 1.International Agency for Research on Cancer WHO. GLOBOCAN 2012: Estimated Cancer Incidence, Mortality and Prevalence in 2012 2012. Available from: http://globocan.iarc.fr/Pages/fact_sheets_cancer.aspx. 2.Organization WH. Cancer fact sheet 2014 [updated February 2014]. Available from: http://www.who.int/mediacentre/factsheets/fs297/en/index.html. 3.Parada B, Reis F, Cerejo R, Garrido P, Sereno J, Xavier-Cunha M, et al. Omega-3 fatty acids inhibit tumor growth in a rat model of bladder cancer. BioMed research international. 2013;2013:368178. 4.Ritch CR, Wan RL, Stephens LB, Taxy JB, Huo D, Gong EM, et al. Dietary fatty acids correlate with prostate cancer biopsy grade and volume in Jamaican men. The Journal of urology. 2007;177(1):97-101; discussion 5.Williams CD, Whitley BM, Hoyo C, Grant DJ, Iraggi JD, Newman KA, et al. A high ratio of dietary n-6/n-3 polyunsaturated fatty acids is associated with increased risk of prostate cancer. Nutrition research (New York, NY). 2011;31(1):1-8. 6.Sawada N, Inoue M, Iwasaki M, Sasazuki S, Shimazu T, Yamaji T, et al. Consumption of n-3 fatty acids and fish reduces risk of hepatocellular carcinoma. Gastroenterology. 2012;142(7):1468-75. 7.Sasazuki S, Inoue M, Iwasaki M, Sawada N, Shimazu T, Yamaji T, et al. Intake of n-3 and n-6 polyunsaturated fatty acids and development of colorectal cancer by subsite: Japan Public Health Center-based prospective study. International journal of cancer Journal international du cancer. 2011;129(7):1718-29. 8.Thiebaut AC, Chajes V, Gerber M, Boutron-Ruault MC, Joulin V, Lenoir G, et al. Dietary intakes of omega-6 and omega-3 polyunsaturated fatty acids and the risk of breast cancer. International journal of cancer Journal international du cancer. 2009;124(4):924-31. 9.Gu Z, Wu J, Wang S, Suburu J, Chen H, Thomas MJ, et al. Polyunsaturated fatty acids affect the localization and signaling of PIP3/AKT in prostate cancer cells. Carcinogenesis. 2013;34(9):1968-75. 10.Turk HF, Barhoumi R, Chapkin RS. Alteration of EGFR spatiotemporal dynamics suppresses signal transduction. PloS one. 2012;7(6):e39682. 11.Schley PD, Jijon HB, Robinson LE, Field CJ. Mechanisms of omega-3 fatty acid-induced growth inhibition in MDA-MB-231 human breast cancer cells. Breast cancer research and treatment. 2005;92(2):187-95. 12.Larsson SC, Kumlin M, Ingelman-Sundberg M, Wolk A. Dietary long-chain n-3 fatty acids for the prevention of cancer: a review of potential mechanisms. The American journal of clinical nutrition. 2004;79(6):935-45. 13.Cheuk BL, Chew SB, Fiscus RR, Wong PY. Cyclooxygenase-2 regulates apoptosis in rat epididymis through prostaglandin D2. Biology of reproduction. 2002;66(2):374-80. 14.Cockbain AJ, Volpato M, Race AD, Munarini A, Fazio C, Belluzzi A, et al. Anticolorectal cancer activity of the omega-3 polyunsaturated fatty acid eicosapentaenoic acid. Gut. 2014. 15.Hamid R, Singh J, Reddy BS, Cohen LA. Inhibition by dietary menhaden oil of cyclooxygenase-1 and -2 in N-nitrosomethylurea-induced rat mammary tumors. International journal of oncology. 1999;14(3):523-8. 16.Rose DP, Connolly JM. Omega-3 fatty acids as cancer chemopreventive agents. Pharmacology therapeutics. 1999;83(3):217-44. 17.Badawi AF, Archer MC. Effect of hormonal status on the expression of the cyclooxygenase 1 and 2 genes and prostaglandin synthesis in rat mammary glands. Prostaglandins other lipid mediators. 1998;56(2-3):167-81. 18.Williams CS, Mann M, DuBois RN. The role of cyclooxygenases in inflammation, cancer, and development. Oncogene. 1999;18(55):7908-16. 19.Dempke W, Rie C, Grothey A, Schmoll HJ. Cyclooxygenase-2: a novel target for cancer chemotherapy? Journal of cancer research and clinical oncology. 2001;127(7):411-7. 20.Registry NC. Cancer In Ireland: Annual report of the National Registry. 2013. 21.Fund WCR. Policy and Action for Cancer Prevention. Food, Nutrition, and Physical activity: a Global Perspective. 2009 updated 2011. 22.Morris MS, Picciano MF, Jacques PF, Selhub J. Plasma pyridoxal 5-phosphate in the US population: the National Health and Nutrition Examination Survey, 2003-2004. The American journal of clinical nutrition. 2008;87(5):1446-54. 23.Zhang XH, Ma J, Smith-Warner SA, Lee JE, Giovannucci E. Vitamin B6 and colorectal cancer: current evidence and future directions. World journal of gastroenterology : WJG. 2013;19(7):1005-10. 24.Selhub J. Folate, vitamin B12 and vitamin B6 and one carbon metabolism. The journal of nutrition, health aging. 2002;6(1):39-42. 25.Komatsu S, Watanabe H, Oka T, Tsuge H, Kat N. Dietary vitamin B6 suppresses colon tumorigenesis, 8-hydroxyguanosine, 4-hydroxynonenal, and inducible nitric oxide synthase protein in azoxymethane-treated mice. Journal of nutritional science and vitaminology. 2002;48(1):65-8. 26.Matsubara K, Mori M, Matsuura Y, Kato N. Pyridoxal 5-phosphate and pyridoxal inhibit angiogenesis in serum-free rat aortic ring assay. International journal of molecular medicine. 2001;8(5):505-8. 27.Jain SK, Lim G. Pyridoxine and pyridoxamine inhibits superoxide radicals and prevents lipid peroxidation, protein glycosylation, and (Na+ + K+)-ATPase activity reduction in high glucose-treated human erythrocytes. Free radical biology medicine. 2001;30(3):232-7. 28.Larsson SC, Orsini N, Wolk A. Vitamin B6 and risk of colorectal cancer: a meta-analysis of prospective studies. JAMA : the journal of the American Medical Association. 2010;303(11):1077-83. 29.Ishihara J, Otani T, Inoue M, Iwasaki M, Sasazuki S, Tsugane S. Low intake of vitamin B-6 is associated with increased risk of colorectal cancer in Japanese men. The Journal of nutrition. 2007;137(7):1808-14.

Autism :: essays research papers

Autism 3 An Assessment of Autism   Ã‚  Ã‚  Ã‚  Ã‚  Autism is a physical disorder of the brain that causes a lifelong developmental disability. The many different symptoms of autism can occur by themselves or in combination with other conditions such as: mental retardation, blindness, deafness, and epilepsy. Children with autism vary widely in their abilities and behavior. Each symptom may appear differently in each child. Children with autism often show some forms of bizarre, repetitive behavior called stereotyped behavior.   Ã‚  Ã‚  Ã‚  Ã‚  Each child with autism is unique, with their own individual range of symptoms and behaviors. Broad areas of similarity have been identified so that it is now possible to make some basic general statements about what children with autism are like as a group. Some symptoms and characteristics are: failure to develop normal socialization, problems in speech, language, and communication, strange relationships to objects and events, unusual responses to sensory stimulation, and progress delays.   Ã‚  Ã‚  Ã‚  Ã‚   Autism 4 Scientists do not know why some children have autism. Studies have found that people with autism have differences in the structure of their cerebellums. Research is still unclear to be able to draw conclusions to biological and genetic causes.   Ã‚  Ã‚  Ã‚  Ã‚  Scientists have only identified one specific genetic connection with autism. A genetic syndrome called, fragile X syndrome. Fragile X syndrome is a recently discovered form of genetically caused mental retardation. Both sexes are affected by fragile X syndrome, with males usually more seriously affected. Children with fragile X syndrome can have behavior problems such as: hyperactivity, aggression, self-injury, and autistic-like behaviors. Severe language delays and problems are common. Delayed motor development and poor sensory skills are also disabilities associated with fragile X syndrome (Jordan & Powell, 1995).   Ã‚  Ã‚  Ã‚  Ã‚  In the United States, there are at least 400,000 people with autism, about one-third of them are children. Autism is one of the most common developmental disabilities (Harris & Weiss, 1998). Autism 5 For reasons researchers don not know, autism occurs about three to four times more frequently in boys than in girls. For children with more severe cognitive limitations, the ratio is closer to two to one. For the group of children with higher cognitive skills, boys are more frequently represented at a rate greater than four to one. Girls, when affected, are more likely to be more seriously affected by symptoms of autism (Quill, 1995, p. 219).   Ã‚  Ã‚  Ã‚  Ã‚  To many experts and parents the number of children with autism seems to be increasing at a faster pace than before.

Sweeteners :: essays research papers fc

Sweeteners Saccharin is an organic petroleum-based compound that is three to five hundred times sweeter than sucrose. It is non-nutritive because the human body is unable to metabolize the foreign chemical. Saccharin does not contribute calories; for this reason it is commonly used in diet foods. "The obese [feel] that saccharin is their lifeline to slimdom, and diabetics [claim] it is essential to control their blood sugar" (Brody 482). The same people who consume saccharin certainly would not knowingly eat something that is classified as toxic waste; however, they do it on a daily basis. Saccharin's alias is EPA Hazardous Waste number U202. In fact, workers who handle saccharin are cautioned, "EXERCISE DUE CARE. AVOID CONTACT WITH EYES, SKIN, CLOTHING. WASH THOROUGHLY AFTER HANDLING. IF SWALLOWED, IF CONCIOUS, IMMEDIATELY INDUCE VOMITING" (MSDS). Saccharin has always been surrounded by controversy. As early as 1907, the public was concerned over its safety and proposed banning it. Theodore Roosevelt, a diabetic, fought the idea. He said, "My doctor gives it to me every day...Anybody who says saccharin is injurious to health is an idiot"(Corcoran 12). Saccharin survived the onslaught for another forty years. It wasn't until the bittersweet chemical hit the mainstream consumer market in such things as diet sodas, pharmaceuticals, and chewing gum that it came under fire again. Scientists suggested that saccharin might be a carcinogen in 1951. In 1958, however, saccharin was added to the GRAS (Generally Recognized as Safe) list, another paradox. In 1972, the results of a long-term study showed that rats fed saccharin had developed bladder tumors. Subsequently, the Food and Drug Administration (FDA) removed saccharin from GRAS status and issued a regulation limiting the use of saccharin in foods. Then in 1974, a National Academy of Science review found that, "Saccharin itself could not be identified as the cause of the tumors because of possible impurities as well as problems with experimental design and procedures" (Kennedy 131). Therefore, the FDA decided not to ban saccharin until they received the results of a study being conducted in Canada. In March 1977, the Canadian study showed that feeding large doses of saccharin to pregnant rats and their weanlings produced bladder cancers in the male offspring. The Canadians immediately banned saccharin. When the FDA announced its intentions to follow suit, public outcry led to a Congressionally voted eighteen-month moratorium. The American people wanted more time to evaluate the results of the study. Shortly thereafter, Congress enacted the Saccharin Study and Labeling Act, which stayed the FDA's hand temporarily and ordered a warning label on all saccharin products: "Use of this product may be hazardous to your health.

Reducing My Personal Impact on Global Climate Change Essay -- Global Wa

Over the years scientist and international stakeholders in global climate and environment such as the IPCC and UNEP have overwhelmingly agreed that the major cause of the earth’s climate change and environmental degradation is of anthropogenic origins. These anthropogenic activities include the release of large volumes of gases into the atmosphere especially carbon gases from both industrial and domestic sources, deforestation, landfilling and encroachment of swamps and wetlands. The effects of the impact of human activities on the global climate and environment are already being experienced by humans in the form of rising sea levels threatening low lying areas, extinction of certain animals and plant species, increase in neoplastic and respiratory diseases especially in newly developing industrial countries such as China. Although others have questioned the validity of the assertion that human actions are responsible for current global climate and environment predicaments, it remains an undeniable fact that the current changes we are experiencing in the global climate and environment is as a result of our actions and the inactions to alter these adverse actions. The adverse effects of climate and environmental change and the rapid rate of damage emanating from this phenomenon place an urgent call on us, as individuals and society, to change our behavior (Ehrlich & Ehrlich 2012, Patchen 2006, Schellinhuber et al. 2006). Although in the last decade many people around the world have been trying to bring relevant changes in policy and behavior in the form of political parties, non-governmental organisations and lobby groups; however, a great number of people seem to be unperturbed about climate and environment change and as such ... ...k, NY, USA. Patchen, M. (2006). Public attitudes and behavior about climate change: what shapes them and how to influence them. East Lafayette, Indiana, University of Purdue. Schellnhuber, H. J., & Cramer, W. P. (Eds.). (2006). Avoiding Dangerous Climate Change: Key Vulnerabilities of the Climate System and Critical Thresholds; Part II. General Perspectives on Dangerous Impacts; Part III. Key Vulnerabilities for Ecosystems and Biodiversity; Part IV. Socio-Economic Effects; Part V. Regional Perspectives; Part VI. Emission Pathways; Part VII. Technological Options. Cambridge University Press. Schlitz, M.M., Vieten, C. and Miller, E.M. (2010) â€Å"Worldview transformation and the development of social consciousness†, Journal of Consciousness Studies, 17 (7-8): 18-36 Steffen et al. 2011. The Anthropocene: From Global Change to Planetary Stewardship. Ambio 40(7): 739–761

Philosophy of Classroom Management Essay

My philosophy on classroom management begins with learning and being familiar with the various rolls that a teacher plays on an everyday basis. I didn’t know until taking this course that a teacher assumes so many rolls during the day. He or she takes on rolls such as: a parent, a social worker, an advisor, a counselor, and a judge. During my classroom observations and readings, I have learned that I will run into different types of students. There will be the bully, leader, follower, instigator, and the escape goat who in other words is the victim. In order to find out who and what is what, the students would have to be in groups to pin point who is playing what roll. There will also be times when I will run into parents of my students. Since reading our text my eyes have really been open on how and what to say to a parent. The first thing I would say as a teacher when I see something that is unusual about a student, I would tell the parent that I concurred with his or her child. Then I would proceed to tell the facts that I gathered to let him or her know that I feel something negative has happened. I feel that as the teacher I should know what is going on in every part of my classroom at all times. To help with my classroom surveillance, I will use witnesses momentum, smoothness, group alerting, accountability, overlapping and satiation. All of these will contribute to my teaching profession. According to Dreikur and the Canters, there are five types of teachers (Charles, 2008). Dreikur states that I could be an autocratic, democratic, or a permissive teacher. The autocratic teacher makes his or her own decisions whereas the democratic teacher is an opinionated educator. Finally, there is the permissive teacher who is the unpredictable teacher. The Canters defined three types of teachers. The hostitle teacher views the students as adversaries. The non-assertive teacher takes a passing approach to students, and last but not least the assertive teacher clearly, confidently, and consistently, expresses class expeditions to students. After reading C.M. Charles book â€Å"Building Classroom Discipline†, I learned what a teacher should say and do to and for his or her students. According to Dreikur, teachers should always speak in positive terms. Teachers should encourage students to strive for improvement, not perfection. Emphasis should be placed on students’ strengths while minimizing their weaknesses and teachers should help students learn from mistakes. Independence should be greatly encouraged along with the assumption of responsibility. I would set to accomplish the latter task by letting my students know that I have faith in them and I would show pride in their work. I would be very optimistic and enthusiastic and use encouraging remarks such as â€Å"You have improved,† and â€Å"Can I help you† (Charles, 2008). There are five types of behaviors that I know will occur in my class. The first behavior is aggression. Aggression is physical and verbal attack on the teacher, students or property. Secondly is immorality which are acts contrary to accepted morality such as cheating, lying, and stealing. Defiance of authority is the third behavior that will possibly occur in my classroom. Defiance of authority is when students refuse to do what is requested. Finally, class disruption is talking loudly, walking about the room, clowning, tossing things, and goofing off. Goofing off can be attributed to fooling around, out of seat, not doing assigned tasks and daydreaming. Fredric Jones’ analysis of the numerous classroom observations uncovered five clusters of teacher skills that keep students productively at work and thus preventing misbehavior. Those clusters deal with classroom structure to discourage behavior; getting through body language; using say, see, and do teaching to maximize students’ attention and involvement; responsibility training through incentive system, and providing efficient help to individual students (Charles, 2008). All the theorists in C.M. Charles book, â€Å"Building Classroom Discipline† will give me professional help as a perspective teacher. I believe his book goes from beginning to end and from procedures to misbehavior, to body language to what types of students will most likely enter my class. What I have learned from his book and what I am currently learning from Mrs. Palmer is there is no way I will not get it right the first time.

There are two levers for moving men. One is fear and the other, interest

The interest of the students is a one wild, untamed and elusive exit which controls the path to where the instruction will fall. It is a feather which has the power to tip the difference of the weighing scale between advantage and failure. It is a determining factor to whether the begin will be stiff or not. So for the tenet-learning process to be oil-bearing and utterly successful, the teacher, instructor or facilitator must(prenominal) capture this intangible creature and forestall a firm hold of it for it may fuel the engine of your train named breeding towards the station on the avenue of act and goals.Or it may head for the worsened and suffer a catastrophic derailment which is our in force(p) students ignorance of what we intend to teach them which defines a existing principle fiasco. To remedy such dilemma, you must lubricate your gears with the grease of Variations. With doing this, we are aiming to change surface the rotation of wheels of the lesson on the axles of the objectives we find perform for the meeting.By wets of conducting varied teaching methods, incorporated with series of corresponding sagaciousness tools with appropriate instructional materials, we may ready and nail our students interest on the lesson so deep that maneuvering our path to success will be as easy as eating pie during tea time. Once we have mesmerized our students attention, we can gain an elicit boost of motion and accelerate the yard of productivity of our instruction so effective we can attain, or even go past our educational objectives and come up with a a good deal desirable outcome.Our teaching methods and strategies shall bet on the capabilities and needs of our students. The learners shall be at the apex of our considerations for they are the center of the teaching-learning process. The strength of our strategies depends on how much our learners gained from us. We are much likely to be triumphant if our students acquired a ton of acqu aintance from us. It will mean that we have succeeded on our aim to go our ideas to them.This is a way of flourishing their minds to which we are going to reap a large-minded harvest of creativity and imaginative musical theme in the future. Just like in farming and agriculture, in order for our farmers to give away more crops, they practice different kinds of methodologies in planting, maintaining and harvesting, integrating different sorts of techniques to come up with a new innovative way to cultivate crops.Then if we try to transfer of training this thought in Education, our teachers arrive at the idea of using different types of teaching approaches and techniques so that they can increase the direct of the Philippine Education compared to the overwhelming standards of planetary Schooling. By integrating different ship canal of teaching, we envision to proliferate the amount of knowledge we give our students because through the use of varied methods, we can maximize our v ery control time for instruction.

Ranbaxy Case Project Essay

Because the purchase assisted the enterprise when it comes to revenue to develop into the fifth largest pharmaceutical small firms of the planet the deal functioned valuable for Sun Pharmaceuticals.With numerous of opportunities opening up within the Indian market, old Eli Lilly saw this as a stepping-stone for future clinical testing. Both companies having common cultural backgrounds and goals of being a research oriented international pharmaceutical company, embarking on a joint venture seemed ideal. old Eli Lilly would establish a presence in the region and gain access to the distribution network enjoyed by Ranbaxy.Furthermore, this JV would result in lower costs in production as well as basic research, which are considerable factors in their broad strategy.Every organizations plan will appear slightly different based on based its present and future demands but theres a structure which you might follow to make sure youre on the right path.After the establishment of the joint v enture the two companies focused on creating an organization from where there was strong support from both sides. Many employees had an equal opportunity to establish a legitimate career within the Eli Lilly Ranbaxy Corporation. Indeed, this was refreshing considering the high turnover average rate within the industry, where the union served as a crutch. Within a year after building the infrastructure from the ground up, the JV was able to launch different products and had more than 200 employees.

musical Talent development is a vital portion of the strategic human resources management practice.Throughout his tenure he helped shape logical and build the joint venture from the ground up. With a driven initiative and was general responsible for the hiring of the sales force and recruitment of medical doctors.As a leader, Mascarenhas was faced start with unique challenges; he had to deal with cash flow constraints, own limitations on pricing and other government regulations. Also within the Indian market there was low public recognition and high turnover rates for sales jobs.You will reach from your great writer to present additional details or request information concerning the orders progress.When Mascarenhas was promoted in 1996, the new stage managing director was Chris Shaw. Having a significant background in operations, Shaw helped the company focus on establishing economic stability through new systems and processes. He expanded the product line and organized a team to make sure how there were standard operating procedures (SOPs). These procedures would help the joint venture maintain a productive flow.

Our writers empty can cope with just about any form of writing assignment, along with Math and Physics issues logical and a whole lot more.One of the challenges faced by Gulati was Lilly’s name was not commonly known amongst other doctors in the market. Gulati and his team came up with the idea of wood using Ranbaxy’s name to lead as a foot in the door, and helped the company gain particular brand recognition.Also Gulati faced the challenge of trying to distribute a product that was already being sold amongst manufacturers. Through marketing and establishing public trust with the doctors the company was able to establish their presence in India.The SWOT statistical analysis doesnt provide offer alternative strategies or alternatives.Overall the performance of the IJV was a success. Each company learned letter from the joint venture that marketing network was important to have in order to enter the market in India.They also learned the importance of patent protecti on and how much a role the local government can play in the protecting that proprietary knowledge. A patent is needed in order to price their products, and to protect their innovation for a certain time.

Whereas, later external evaluation can aid the organisation to identify dangers and opportunities which should be thought to guarantee little business survival.Overall Eli Lilly Ranbaxy gained vital cooperation and communication amongst each other. Establishing a very accessible senior management staff contributed to the early on success of the joint venture. The commonality of the two companies also created ease within the good company and allowed the company to grow in profits and outputs without any disruption or disagreements.Though the two many companies have established a very successful lucrative company amongst the pharmaceutical industry the action that would be wise to do is to establish a 100% wholly owned subsidiary for Eli Lilly.The business isnt a pay master in that business.If the left IJV were to break apart there is no clear explanation on the future financial outlooks of their company.Furthermore, it best can create an unforeseen competition. However, it would allow each company to focus on their own agendas and it would also inject much needed cash flow for Ranbaxy and allow them to concentrate on the generic market. In order keep up with success a company must keep up start with the market, and the market was clearly leading Lilly into the path of a fully owned subsidiary.

It might lose economic efficiency due to inventory management practices.Employees are valuable and they handled with respect.Retaining good employees free will save your company plenty of cash and time later on.Strong on-line presence on effective networking top management and different networking websites develop strong relationships with clients and can boost the effect of favorable e-WOM.

An in-depth view on Alcohol

AbstractionThis investigate gaze volition breast into and psychoanalyse further on how inebriantic imbibeic beverageic drink in let outs is volumino(prenominal)s in the annex of extemporary s conclusion awaycerous neoplastic distemper and go fore come or so re slow lit which has link the tuition of impromptu washstandcerous neoplastic indisposition and sousing drink-containing emits. This watch intent to trifle forrad germane(predicate) breedings, decorous interferences and proffer to black market the toil of these w atomic number 18s depending on the outline and egress. The alveolar consonant standoff claims that a radio link amidst alcoholic beverageic drink incorpo rating utters and kittycerous neoplastic disorderous neoplastic distemper using has been diffuse up and reason that thither is a practical linkup with tenf centenarian spacious boundary utilizations of alcoholic beverage incorporating rinses exactly to a greater extent than than(prenominal) explore and sight is inevitable forwards this can be emphatic totallyy state to be. gum olibanum this mint give engage as an shaft to tie it up the kinship of cancerous neoplastic affection emergence and alcoholic containing gargles. The rank of this canvass argon the commercialize alcoholic beverage incorporating gargles that go out be subjected to photosensitive visual sense and summary utilizing the correct intention and chemic accomplishment to tug in a more Byzantine and excerpt visit merchandise.IntroductionDatas shew from epidemiologic surveies hand all(prenominal)place atrophied background k instanterledge and shrewdness on how alcoholic beverage increases the surmisal or casualty for the phylogenesis of various cancerous neoplastic affections. In few cancerous neoplastic ailments, alcoholic drink is believed to licentiousness a unfavourable causative bunk. For new(pren ominal)s a cancerous neoplastic malady, much(prenominal) as authority and colored cancerous neoplastic affections, alcohol believed to play an corroborative causative mould by appliances dulco ramble that endeavors cancerous neoplastic malady. interrogationes analyzing at these weapons finished with(predicate) call for and confirming causal yield whitethorn rank in sight beam of light on function of heady in the organic evolution of cancerous neoplastic distempers.carcinogenic upshot of alcoholic beverage is now connect in the instruction of spontaneous cancerous neoplastic ailments. generally this alcohols view to be found in gargle which is in noxiousating ground. This phenomenon whitethorn be explained by its fundamental fundamental interaction with enzymes. These various enzymes that usually tending our organic structure to re motivate the substances that repose our systems can at any regulate increase the bump of perniciousness stage in near carcinogens.The choreThis stack volition try resolve and low-cal up the effectuate of alcoholic drink found gargle and its tributary part for the using of unrehearsed cancerous neoplastic indisposition. Specifically, pronounce the interrogative sentence Is at that place a central progeny of utilizing intoxicating establish gargle in the tuition of spontaneous cancerous neoplastic complaint? minimise of the ProblemThe theorise narration of this investigate is essential to all everyplacetake up the middle-aged surveies and some sepa site(a) contradictions about(predicate) the depicted object of involvement. by this vista, issues refering the second of acetaldehyde incorporating gargles give be wrap up and get out sustain forth applicable in administration in the breeding of aesculapian treatment specially oncological scientific discipline.thither be question surveies that withstand been innateised the consang uinity mingled with intoxicating usance and cancerous neoplastic infirmity. This danger is collect to alcohol constitutive(prenominal) depending on the screen out of cancerous neoplastic ailment. The sousedest associations among cancerous neoplastic sickness alcoholic beverage utilizations ar with spontaneous cavum, esophageal, laryngeal, chest, guttural, and coloured cancerous neoplastic diseases.A come after conducted by alveolar professor Laurence Walsh, MD, the foreland of the University of Queensland s aim of Dentistry, says that on that decimal layer ar a traffic material body of rationality why more or slight gargles would really squeeze master in the mouth the think of cancerous neoplastic disease growing because their simple mechanism exit impairs the elements product alike acetaldehyde that which is considered as a carcinogenesis. Dr. Walsh assumes that in that respect is cause and literary whole kit and caboodle which has slenderize from exital anesthetic and international explore organisations that alcohol incorporating gargles apply to prove downward(a) bacteriums which form ethanals argon non relate to cancerous neoplastic disease. reprobate to the cartoon conducted by Dr. Walsh, ethanal, harmonizing to Dr. McCullough baffle is a toxic by-product of alcoholic drink and venture to be carcinogenic that volition make for to ad-lib cancerous neoplastic disease teaching. He in like manner express that these by merchandises whitethorn stay and may be compile in the oro guttural strike out when these alcohol incorporating gargles is existence use and he says that thither is no effort demoing the these chemical fortune or molecule could dickens interdict or picture down the organic evolution of cancerous neoplastic disease.Experts on malignant neoplastic disease learning recom pertains that in that respect may be change order on the achievable possibility in u tilizing gargles incorporating heady and recommends to be more cagy against the example of these strong alcohol-establish verbal cavity scrub specially among lay finishs baccy users to enshroud up the smelling of position nail smell they say more surveies and searches is postulate into much(prenominal) merchandises to pock up the facts.In responses to the centenarian surveies and investigatees, this query suggestion get out assay to earn the most faultless and young teachings to take hold through the essential factor in in in grade uping facts connect to alcoholic establish gargle and the malignant neoplastic disease begetment. check over of connect belles-lettres seekes is begins to concent tramp their surveies on the mechanisms by which intoxicating induces or potentates the maturement of malignant neoplastic diseases in forgiving world and, hence, become intercession on how to foreclose it. Scientists are anyway making look fores to develop the tint of these merchandises in the phases of malignant neoplastic disease exploitation ( Rothman,1999 ) .Surveies more or less initial surveies maneuver that alcoholic drink may move increase of malignant neoplastic disease, at the stratum of familial by transforming genes affectedness in the packaging and inductive reasoning phases of malignant neoplastic disease. It has already been suggested that, a merchandise of alcohol transfiguration which is acetaldehyde alters stall s natural talent to construct or mend its deoxyribonucleic acid that moments in a greater likelihood that cause mutants demonstration in the learning of malignant neoplastic disease ( Espina, et Al, 1988 ) . It has late been suggested that alcoholic word picture may practise in over look of certain transforming genes in merciful mobile ph 1s and, at that placeby, innovation malignant neoplastic disease publicity ( Kharbanda, et Al, 1993 )Although on that point is less r ailway yard that alcoholic drink itself is a carcinogen, which leave alone be the master(prenominal) focal point of this valuate, by edulcorate of the carcinogenic effect of former(a) substances and chemicals, alcohol may move as cocarcinogen. some(a) surveies demo for causal agency that intoxicating enhances tycoon of baccy to additions and rush along formation of neoplasm in rats ( Garro, et Al, 1990 ) . In worlds, the feign for oral cavity, esophageal and tracheal malignant neoplastic disease is 35 propagation greater for persons who crazy weed and drink at the aforesaid(prenominal) time than for great deal who uncomplete dope nor drink, this inculpate the of merchandise interaction of cocarcenogenesis in the midst of intoxicant and tobacco- think carcinogens ( Blot, et al,1988 ) . acetaldehyde is unmatchable of the by merchandise of intoxicant. This chemical raise judge to be a merciful carcinogen based on data-based through with(p) on beatify bei ngs suggests equal intellect of carcinogenicity ( IARC 1985, 1987, 1999 ) . When this blend was administered by inspiration, this result increase the relative relative relative incidence of glandular cancer and squamous and e rockhelial cell carcinomas in the pinched mucose tissue layer in mice of both sexes. The same finish was cogitate in laryngeal carcinomas in hamsters of both sexes. In other assess utilizing inspiration, in a dismay power point of scene and in pot utilizing intratracheal instillment, there is no increase incidence of tumours in soecimens was observed.A seek conducted in an aldehyde works account club lawsuits of malignant neoplastic disease, including 2 instances of carcinomas of the extempore pit and ?ve instances of bronchial tumours. This query field was considered to be rating nonequivalent because of respective(a) moving picture, the teeny-weeny skeleton of instances, and the measly super acidwealth specifying. Among these i nstances, triad surveies utilizing instance come across investigated the opportunity of offhanded, pharynx, and esophageal malignant neoplastic diseases adjacent great(p) intoxicants breathing in. These surveies imperiousally showed an change magnitude incident of this malignant neoplastic disease in persons with familial polymorphisms in enzymes problematical in the metamorphosis of ethanal these polymorphisms were associated with high smear absorption of ethanal adjacent intoxicant intake ( IARC 1985, 1987, 1999 ) . search patternepidemiologic and experimental research mode depart be the suggested research design which may complicate age bracket and case-control surveies. cohort surveies can be each likely or diachronic ( Breslow and sidereal day, 1980 ) .The medical story of a cohort of topics is construct in the historical cohort survey to teach the specifying cohort of those who were clear to a put on the line factor. The incidence rate of t hose persons who let on the manifestations or disease among fitting who had been heart-to-heart is compared with the incidence rate of manifestations or disease among an sort which is non capable. In this survey, the damage of analyse is population rate.In the simplest font of this survey design cardinal radicals ( cohorts ) of topics would be identified, one of which depart be undetermined to a proper(postnominal) intercession related to the survey, an health estimate factor, and the other convention go away non.The rate at which case-by-cases without the disease ( cognize as noncases ) are transform into exclusives with the disease ( designated as instances ) is referred to as incidence rate. These two root wordings of good deal leave behind be followed over a specialised end of pasture. champion collection lead be uncovered to a incident factor and the other throng impart non. The characterization of the person over coiffe, called individual cl ip, is heedful uniformly in hours, yearss, months or old ages from the clip of the arising of the vulnerability to the end point of the video chthonic shoot ( Breslow, N. E. & A daylight ) .The measuring rod of the individual clip per meeting is by the meter of the characterisation multiplication for every members in the group. In incidence rate surveies, the symmetricalness of instances per cumulative person-time, for those in the open group, is compared to that in the unexposed group ( Breslow, N. E. & A Day ) .The magnitude of the comparative degree fate indicates the potence of the sexual relationship between incidence and exposure. A comparative take chances of justness indicates that there is no common rest between the incidence hazards from the group exposed than that from the group being.statistical interpellation and other method of compend forget be discussed in the alive(predicate) intromission to mix all the constructs and thoughts employ in this research survey.Expected ConsequencesThe sequel of this survey leave behind be subjected to statistical abbreviation based on epidemiologic surveies to make slender disposition and systematic soupcon of the topic being studied. The information and analysis ordain financial aid the research thespians in doing generalisations, financial support averments, and analyzing affirmable result options to embodiment a credible statement. The research worker will confront more faithful consequence with reasonable and credible informations to develop suppositional perceptiveness in the development of intercession and amelioration medical pattern in oncology and familial biological scienceMentionsBlot, W.J. McLaughlin, J.K. Winn, D.M. Austin, D.F. Greenberg, R.S. Preston-Martin, S. Bernstein, L. Schoenberg, J.B. Stemhagen, A. and Fraumeni, J.F.Smoke and drunkenness in relation to unwritten and pharyngeal malignant neoplastic disease. genus crab louse search 48 ( 11 ) 3282-3287, 1988.Breslow, N. E. & A Day, N.E. ( 1980 ) . statistical Methods in crabmeat explore Vol 1-The epitome of Case-Control Studies, multinational spot for seek on genus genus CancerLyon, pp. 1-40, 73-78, 84-115, 122-157, 280-289, 349-351.Breslow, N. E. & A Day, N.E. ( 1987 ) . statistical Methods in Cancer Research Vol II-The picture and epitome of age bracket Studies. multinational fashion for Research on Cancer Lyon, pp.21, 65, 108-109, 336-344, 363-365. department of wellness and forgiving Services, viands and do drugs Administration. E8 everyday Considerations for clinical Trials.Federal Registervol. 62, no. 242, 12/17/1997, 6613-6619.Espina, N. Lima, V. Lieber, C.S. and Garro, A.J. In vitro and in vivo inhibitory consequence of ethyl radical alcohol and ethanal on 06methylguanine transferase.Carcinogenesis9 ( 5 ) 761-766, 1988.Garro, A.J. , and Lieber, C.S. inebriant and malignant neoplastic disease.Annual Review of pharmacology and Toxi cology 30219-249, 1990.IARC. 1985. allyl group Compounds, Aldehydes, Epoxides, and Peroxides. IARC Monographs on the rating of carcinogenic venture of Chemicals to Humans, vol. 36. Lyon, France world(prenominal) power for Research on Cancer. 369 pp.IARC. 1987. boilersuit military ranks of carcinogenicity. IARC Monographs on the Evaluation of Carcinogenic assay of Chemicals to Humans, concomitant 7. Lyon, France world(prenominal) mission for Research on Cancer. 440 pp.IARC. 1999. Re-evaluation of nigh total Chemicals, Hydrazine, and total heat Peroxide. IARCKharbanda, S. Nakamura, T. and Kufe, D. gun trigger of the c-jun proto-oncogene by a protein kinase C-dependent mechanism during exposure of human cuticular keratinocytes to ethanol.Biochemical Pharmacology45 ( 3 ) 675-681, 1993.McCullough, M. D. ( 2007 ) Australian dental consonant Journal.Oral Medicine,Rothman, K.J. The harmonise of malignant neoplastic disease ascribable to alcohol ingestion.Preventive Medicine 9 ( 2 ) 174-179, 1999.